Pharmaceutical Hot-Melts Research 관련 자료 입니다;
Overview
Purpose: Provide on the one hand an efficient screening tool for Hot-Melt Extrusion (HME) formulation development and make available on the other hand rheological parameters for process development and optimization, as well as for modeling calculations for compounding and extrusion. Methods: Rheometry and polarization light microscopy up to 300 °C with well-defined heating and cooling rates, temperature profiles and shear rates as well as oscillatory testing.
Results: This combined method requires only a small sample volume and delivers efficiently significant and well-correlated rheological data and microscopic images, which allow to investigate formation and stability of solid solutions or crystalline dispersions. Moreover these results deliver at the same time meaningful parameters for extruder dimensioning and processability and for simulation calculations of the pharmaceutical
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